The cited source was located and retrieved directly. NCCIH states that there have been only a small number of studies on "detoxification" programs in people, and while some have had positive results on weight and fat loss, insulin resistance, and blood pressure, the studies themselves have been of low quality, with study design problems, few participants, or lack of peer review . NCCIH further states that a 2015 review concluded there was no compelling research to support the use of "detox" diets for weight management or eliminating toxins from the body, a 2017 review said juicing and "detox" diets can cause initial weight loss because of low calorie intake but tend to lead to weight regain once a normal diet resumes, and there have been no studies on long-term effects of "detoxification" programs .

The underlying 2015 review, published in a peer-reviewed dietetics journal, reports that although the detox industry is booming, there is very little clinical evidence to support the use of these diets, and a handful of clinical studies showing that commercial detox diets enhance liver detoxification and eliminate persistent organic pollutants are hampered by flawed methodologies and small sample sizes . It also notes that preliminary evidence for detoxification properties of certain foods such as coriander, nori and olestra comes mostly from animal studies , and that to the authors' knowledge, no randomised controlled trials have been conducted to assess the effectiveness of commercial detox diets in humans .

Independent expert commentary aligns. A registered dietitian and Academy of Nutrition and Dietetics spokesperson stated that "For healthy adults, there is no strong evidence that detox diets, liver cleanses, or colon cleanses improve health" , and reporting notes that the body's built-in detox systems remove waste and chemicals mainly by way of the liver and kidneys, and that promoters' claimed benefits are not backed by scientific evidence .