On assertion (A), tomatoes as a lycopene source. The evidence supports this in dietary terms. About 85% of dietary intake of lycopene comes from tomato and tomato-based sauces and other products , and a separate source puts the US figure at roughly 80%. Roughly 80% of the lycopene intake in the United States comes from tomato products . However, on a per-gram basis raw tomatoes are modest: Fresh tomatoes pack 2,573 mcg into a 100 g serving, according to the USDA , roughly 2.5 mg per 100 g. Concentrated and dried tomato products are far higher. Sun-dried tomatoes are the richest tomato food in lycopene, with 46 mg per 100g , and the range for tomato paste, 5.4 to 150 mg per 100 g, reflects how concentrated the product is . At least one non-tomato food exceeds all of these: Gac fruit contains approximately 70 mg of lycopene per 100 grams of flesh, one of the highest lycopene concentrations of any food in the world .

On assertion (B), fat-solubility and avocado. This is the strongest-supported part of the post, and it traces to a real, specific, well-cited human trial. The mechanism is established: dietary carotenoids are fat-soluble phytochemicals that circulate in lipoproteins , and carotenoids are best absorbed with fat in a meal; chopping, puréeing, and cooking carotenoid-containing vegetables in oil generally increase the bioavailability of the carotenoids they contain .

The specific avocado finding comes from Unlu et al. 2005: the objective was to assess whether adding avocado fruit as a lipid source enhances carotenoid absorption in humans, using healthy subjects (n = 11 per study) in two crossover, postprandial studies; the effect of adding 150 g avocado to salsa on lycopene and β-carotene absorption was examined in Study 1 . The result: the addition of avocado to salsa enhanced lycopene and β-carotene absorption (P < 0.003), resulting in 4.4 and 2.6 times the mean AUC after intake of avocado-free salsa, respectively . A second arm used salad: supplementing 150 g avocado or 24 g avocado oil to salad similarly enhanced absorption (P<0.01), resulting in 7.2, 15.3, and 5.1 times the mean AUC after intake of avocado-free salad . Critically for the post's framing, neither the avocado dose nor the lipid source affected carotenoid absorption , and the enhancement is attributed primarily to the lipids present in avocado . Avocado is not special. It is a fat delivery vehicle.

On assertion (C), the longevity framing. Evidence for tomato/lycopene intake and mortality exists but is observational and modest in magnitude. In one large prospective cohort, total mortality was statistically significantly inversely associated with intake of raw tomato (HR, 0.95 [95% CI, 0.91-0.99]), tomato catsup (HR, 0.93 [0.89-0.97]), and moderate lycopene intake (HR, 0.88 [0.85-0.93]) . In that same study, dietary intake of raw tomato (HR, 1.04 [0.96-1.14]) and tomato catsup (HR, 1.00 [0.93-1.08]) were not related with cancer mortality . A meta-analysis found small associations: high intakes and high levels of lycopene compared to low amounts were associated with a 5% lower risk (Pooled RR: 0.95, 95% CI: 0.92-0.98) .

Isolated lycopene has performed poorly in intervention trials. Most small-scale intervention studies have found little-to-no benefit of lycopene supplements in reducing the incidence or severity of prostate cancer in high-risk patients , and a meta-analysis concluded that tomato extracts or lycopene treatment yielded no significant effect on PSA level compared to the control .

On the #NAD tag. The post makes no NAD claim in text but attaches the hashtag. The current state of that literature: evidence for an age-related decline in NAD+ levels in humans has been consistently observed only in a limited number of studies, and although preclinical studies support the idea that NAD+ precursor supplementation is a promising strategy to promote healthy ageing, human clinical trials have shown limited efficacy . Similarly, oral NR or NMN consistently elevate circulating NAD⁺ by ~130-150%, yet short-term studies in older adults reveal minimal improvement in cognition, vascular function, or muscle performance .